Thalidomide

Thalidomide was a drug that was prescribed to pregnant women in the deep 1950s and early 1960s to help combat snap distemper. It effectively reduced the symptoms of morning sickness in those women, still at a horrible cost. Many of the children born from women who took Thalidomide dudoughnut maternal quality were born with give defects and were c each(prenominal)ed Thalidomide babies. In reference to the stereochemistry of Thalidomide, in that respect is barely one chiral carbon, and thus just carmine isomers. Thalidomide exists in two stereoisomers, S-thalidomide, which is a sedative that calms nervousness, and R-thalidomide, which was found to be a teratogen that causes birth defects. The carbon atom from the carbon-nitrogen bond connecting the two main ring structures is chiral, as shown on the attached allowance paper. The R-thalidomide isomer is the one that causes all the problems with birth defects, so one index think that if the S-thalidomide isomer was dispo sed to patients instead, there wouldnt take away been such a dread(a) problem. That, however, isnt the case. Humans convert the S-thalidomide into R-thalidomide once in the body, so it really doesnt matter which enantiomer is taken, it would pose toxic effects to the babies of the pregnant women anyway.

Although the use of Thalidomide for morning sickness and its libellous effects to the babies has been called one of the biggest medical tragedies of modern measure, there was some good to come from finding the no-account results. The Thalidomide calamity led to much stricter testing being necessitate for dru gs and pesticides before they can be licens! ed. In addition, it has been found to be a viable treatment for many medical conditions including dual myeloma in people who have been recently found to have this disease. Its also used to treat and prevent strip down symptoms of erythema nodosum leprosum(ENL or leprosy).If you want to get a full essay, send it on our website: BestEssayCheap.com

If you want to get a full essay, visit our page: cheap essay